Ultrabithorax and the evolution of insect forewing/hindwing differentiation

Decades have passed since the stunning four-winged phenotype of the Drosophila Ultrabithorax (Ubx) mutant was reported, and accumulating knowledge obtained from studies on Ubx in Drosophila has provided a framework to investigate the role of Ubx during insect wing evolution. With several new insights emerging from recent studies in non-Drosophila insects, along with the outcomes of genomic studies focused on identifying Ubx targets, it appears to be an appropriate time to revisit the Drosophila paradigm regarding insect wing development and evolution. Here, I review the recent findings related to Ubx during wing development, and discuss the impact of these findings on the current view of how Ubx came to regulate wing differentiation in the evolution of insect flight structures.