Interaction of plant defense compounds with the insect gut: new insights from genomic and molecular analyses

The co-evolutionary conflict between insect herbivores and their host plants is profoundly influenced by biochemical reactions associated with passage of toxin-laden plant material through the herbivore digestive canal. Insect herbivores provide excellent models in which to understand the mechanistic interplay between nutrition and detoxification, how plant defense compounds hijack these processes, and how insects adapt to host defense chemistry. Expanding genome sequence information and genetic approaches to manipulate gene function in both interacting partners are providing new insights into the genetic underpinnings of host preference and plasticity in gut physiology. Fundamental knowledge gained from these studies has practical application in understanding how insects evolve resistance to pesticides, and may also inform efforts to better understand how plant chemicals impact human health.