Mathematical principles of production management and robust layout design: Part II. Upscaling to a 1000-ton/year recirculating aquaculture system (RAS)

► Design and management of a large-scale, intensive RAS were addressed. ► A queuing-network, robust 6σ design, and optimization models were developed, combined and applied. ► Design criteria-turnover, fish biomass density, culture tank utilization, accommodation of two species-were met. ► The solution reflects local aquatic conditions; methodology can be applied elsewhere.