DMSO modifies the permeability of the zebrafish (Danio rerio) chorion-Implications for the fish embryo test (FET)

With respect to the fish embryo test, results indicate that DMSO may be used without complications as a solvent, however, only at a maximum concentration of 0.01% (0.1 mL/L) as already indicated in the OECD difficult substances paper (OECD, 2000).