| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6382696 | Aquatic Toxicology | 2013 | 10 Pages |
Abstract
⺠We cloned the ecdysteroid receptor (EcR) and the retinoid-X-receptor (RXR) of the opposum shrimp Neomysis integer. ⺠We developed a chimeric Gal4 cell reporter system to investigate the heterodimerization of NiEcR-CrcRXR in vitro. ⺠PonA facilitated dimerization, while the insecticide tebufenozide with endocrine disruptive activities had no effect. ⺠In silico binding of tebufenozide with NiEcR revealed steric hindrance, while PonA fitted perfectly. ⺠Neomysis integer juveniles exposed to tebufenozide, in vivo, showed no molting disturbances.
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Authors
R. De Wilde, L. Swevers, T. Soin, O. Christiaens, P. Rougé, K. Cooreman, C.R. Janssen, G. Smagghe,