Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6588122 | Chemical Engineering Journal | 2011 | 5 Pages |
Abstract
A facile preparative method for stable isotope labeled molecules is widely demanded in analytical standard chemicals, biochemical science and medical applications. A rapid 16O-18O isotope exchange reaction of carbonyl group to attain a high isotopic purity has been demonstrated using a capillary column reactor packed with Dowex 50WX4 resin as a solid acid catalyst. Thus, carbonyl-18O compounds such as benzaldehyde-18O, 3-/4-nitrobenzaldehydes-18O, 1-naphthaldehyde-18O and acetophenone-18O were produced with more than 95 at.% purity under the stable flow operation at a moderate temperature within a residence time of 51 s, when the acetonitrile solutions of carbonyl-16O compounds were injected to the reactor with 100 eq. mol of H218O. The maximal product isotopic ratio, zmax, has been formularized as zmax = (x0y + z0)/(y + 1), where x0 and z0 are isotopic ratio of H2O and carbonyl group as reactants, respectively, and y is the molar ratio [H2O]/[carbonyl group]. The achievement ratio of the actual isotopic ratio (z) to theoretical zmax has reached 0.98 or higher.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Yuji Kawanishi, Yasuzo Suzuki, Akira Miyazawa,