Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7138770 | Sensors and Actuators B: Chemical | 2018 | 20 Pages |
Abstract
A hypoalbuminemia diagnosis kit, based on an extraordinary optical transmission sensor, for accurate and fast measurements of albumin concentrations in human serum was demonstrated. First, using nanohole arrays, the sensitivity of the sensor was confirmed to be approximately 460ânm/RIU by theoretical simulations and using standard solutions with specific refractive indices. In the preliminary study of albumin measurements, non-labeled detection of a difference in albumin concentration of approximately 10âmg/ml was achieved with a spectral peak shift of 0.8972ânm and proved to be capable of diagnosing hypoalbuminemia without a surface modification process. Additionally, we successfully classified 100 samples with different concentrations into normal and hypoalbuminemia groups with a probability greater than 98%. According to the results, the hypoalbuminemia diagnosis kit has a potential to be practically employed for real-time, preclinical, label-free diagnosis with integration of advanced microfluidics and miniaturized optics.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yeji Lee, Hyerin Song, Heesang Ahn, Jong-ryul Choi, Kyujung Kim,