| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8298827 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2011 | 10 Pages |
Abstract
⺠Mitochondrial damage and hypoxia is important in alcohol-dependent hepatotoxicity. ⺠Cellular bioenergetic reserve capacity is decreased by chronic ethanol exposure. ⺠Lower reserve capacity increases the sensitivity of cells to nitric oxide and hypoxia. ⺠Nitric oxide and hypoxic stress lower bioenergetics in response to ethanol in vivo.
Keywords
HIF-1αCcOXOCRCYP2E1ALDH2alcohol/ethanolFCCPRNSiNOSEtOHROSaldehyde dehydrogenase 2Ethanolinducible nitric oxide OxygenBioenergeticinducible nitric oxide synthasecytochrome P450 2E1cytochrome c oxidaseReserve capacityhypoxia-inducible factor-1αOxygen consumption rateNitric oxidecarbonyl cyanide-p-trifluoromethoxyphenylhydrazonereactive nitrogen speciesReactive oxygen species
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Authors
Blake R. Zelickson, Gloria A. Benavides, Michelle S. Johnson, Balu K. Chacko, Aparna Venkatraman, Aimee Landar, Angela M. Betancourt, Shannon M. Bailey, Victor M. Darley-Usmar,