Article ID Journal Published Year Pages File Type
8298833 Biochimica et Biophysica Acta (BBA) - Bioenergetics 2011 6 Pages PDF
Abstract
►The permeability transition pore (PTP) is an inner membrane mitochondrial channel. ►The rat-selective toxicant norbormide (NRB) is species-selective for PTP opening. ►The PTP-inducing effect is lost in mitoplasts (devoid of the outer membrane). ►NRB transport depends on the outer membrane protein TSPO. ►We have tentatively identified the TSPO residues responsible for transport of NRB.
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