| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8298864 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2010 | 7 Pages |
Abstract
The five complexes (complexes I-V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.
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Authors
Natalya V. Dudkina, Roman KouÅil, Katrin Peters, Hans-Peter Braun, Egbert J. Boekema,