Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8299168 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2008 | 9 Pages |
Abstract
Both the contribution of mitochondria to intracellular calcium (Ca2+) signalling and the role of mitochondrial Ca2+ uptake in shaping the cytoplasmic response and controlling mitochondrial function are areas of intense investigation. These studies rely on the appropriate use of emerging techniques coupled with judicious data interpretation to a large extent. The development of targeted probes based on the molecular engineering of luminescent proteins has allowed the specific measurement of Ca2+ concentration ([Ca2+]) and adenosine trisphosphate concentration ([ATP]) in intracellular organelles or cytoplasmic subdomains. This approach has given novel information on different aspects of mitochondrial homeostasis.
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Authors
Alessandro Rimessi, Carlotta Giorgi, Paolo Pinton, Rosario Rizzuto,