Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival

Schematic model depicting the possible role of nuclear INPP4A in regulating cell proliferation and apoptosis. In this proposed model, INPP4A shuttles between the cytosol and the nucleus under normal conditions and ratio between the two compartments is maintained depending upon the cell's requirement. Transient nuclear localization of INPP4A is essential to the maintenance of normal proliferation. In cancerous condition, INPP4A fails to localize to the nucleus. This may occur due to a dysregulated import-export machinery. This, in turn, contributes to loss of cell cycle control, aberrant growth and onset of oncogenic event.301