Identification of conserved and novel microRNAs in Manduca sexta and their possible roles in the expression regulation of immunity-related genes

Article ID	Journal	Published Year	Pages	File Type
8321792	Insect Biochemistry and Molecular Biology	2014	11 Pages	PDF

Abstract

A Venn diagram showing that Manduca sexta miRNA or miRNAâ levels decreased (green circles, I/C <80%) or increased (red circles, I/C >125%) in hemocytes (H) and fat body (F) after the immune challenge. The negatively correlated mRNA level changes of their putative immunity-related target genes suggest the expression regulation of innate immunity by miRNAs.270

Keywords

TEP PRR PAP IMD MAP kinase kinase DSCAM SOCS JAK-STAT Jun N-terminal kinase aPKC PPBP SPH UBC PIAS PGRP MLK MEKK β-1,3-glucan recognition protein JRA βGRP TAK IKK PSP SPZ ERK AMP AOP CTL Jnk IML IAP ECSIT IκB kinase MAPK MKK SERPIN Spätzle ALK hem Insect immunity Immulectin Posttranscriptional regulation Illumina sequencing suppressor of cytokine signaling serine proteinase homolog Tollip extracellular signal regulated kinase PVR phenoloxidase and its precursor Anaplastic lymphoma kinase C-type lectin Mask Janus kinase-signal transducer and activator of transcription MEK kinase inhibitor of apoptosis protein inhibitor of activated Stat Serine proteinase inhibitor hemipterous Lepidoptera Thioester-containing protein Peptidoglycan recognition protein atypical protein kinase C mitogen-activated protein kinase Antimicrobial peptides immune deficiency Mixed-lineage kinase pattern recognition receptors