Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8336525 | The Journal of Nutritional Biochemistry | 2016 | 33 Pages |
Abstract
Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14 M, 9 W, mean age 46 years, S.D.=14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing 150-mg (L-BE), 300-mg (M-BE) and 600-mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. Plasma glucose, insulin and incretins (GIP and GLP-1) were measured 0-120 min, and plasma 8-isoprostane F2α, together with arterial stiffness by digital volume pulse (DVP) was measured at 0 and 120 min. Early plasma glucose response was significantly reduced following H-BE (n=22), relative to CON, with a mean difference (95% CI) in area over baseline (AOB) 0-30 min of â0.34 mmol/l.h (â0.56, â0.11, P<.005); there were no differences between the intermediate doses and placebo. Plasma insulin concentrations (AOB 0-30 min) were similarly reduced. Plasma GIP concentrations (AOB 0-120 min) were significantly reduced following H-BE, with a mean difference of â46.6 ng/l.h (â66.7, â26.5, P<.0001) compared to CON. Plasma GLP-1 concentrations were reduced following H-BE at 90 min. There were no effects on 8-isoprostane F2α or vascular function. Consumption of blackcurrant extract in amounts roughly equivalent to 100-g blackcurrants reduced postprandial glycemia, insulinemia and incretin secretion, which suggests that inclusion of blackcurrant polyphenols in foods may provide cardio-metabolic health benefits. This trial was registered at clinicaltrials.gov as NCT01706653.
Keywords
GLP-1time of maximum concentrationNEFAGIPtmaxCmaxAOBRandomized controlled trialAnthocyaninsnon-esterified fatty acidsIncretinsinsulincontriacylglycerolTAG یا triacylglycerols Berriesmaximum concentrationcontrol treatmentPolyphenolsglucagon-like peptide-1Postprandial glycemiaglucose-dependent insulinotropic polypeptide
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Authors
Monica L. Castro-Acosta, Leanne Smith, Rosalind J. Miller, Danielle I. McCarthy, Jonathan A. Farrimond, Wendy L. Hall,