| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8349321 | Pesticide Biochemistry and Physiology | 2015 | 23 Pages |
Abstract
- Flupyradifurone (FPF) is a new insecticide acting on nicotinic acetylcholine receptors (nAChR).
- FPF is distinct from other commercial nAChR agonists and contains a novel bioactive butenolide pharmacophore.
- FPF exhibits fast action against a broad spectrum of sucking insects and has an excellent safety profile.
- N-2,2-Difluoroethyl residue in FPF increases insecticidal activity and prevents oxidative metabolization.
- Lack of CYP6CM1-mediated cross-resistance to imidacloprid is supported by docking studies in silico.
Keywords
nAChRBgTxIRACIRMbungarotoxinIMDFPFRMSDSARDFTAChAcetylcholineImidaclopridButenolidesMode of actionCNSStructure–activity relationshipscentral nervous systemInsect resistance managementroot mean square deviationDensity functional theorypymPymetrozineInsecticide Resistance Action Committeenicotinic acetylcholine receptors
Related Topics
Life Sciences
Agricultural and Biological Sciences
Agronomy and Crop Science
Authors
Peter Jeschke, Ralf Nauen, Oliver Gutbrod, Michael E. Beck, Svend Matthiesen, Matthias Haas, Robert Velten,