| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8349348 | Pesticide Biochemistry and Physiology | 2015 | 32 Pages |
Abstract
- Use of UAS-RNAi allowed for the targeted knockdown of genes putatively involved in DDT resistance.
- Cyp4g1, Cyp6g1, Cyp12d1, Lcp1, Mdr50, Mdr65, and Mrp1 were determined to be involved in DDT resistance.
- Increased DDT sensitivity upon dsRNA injection of Mdr50, Mdr65, and Mrp1 implicated these genes in DDT efflux and resistance.
Keywords
DDDP450sdichlorodiphenyldichloroethaneddH2OdsRNAP450NHSMRPRT-qPCRGSTGlcMDRGC/MSdouble stranded RNAABC transportersATP-binding cassette transporterDDTcytochrome P450 monooxygenaseResistanceDrosophila melanogasterCuticular hydrocarbonsgas chromatography/mass spectrometrygas–liquid chromatographyglutathione-S-transferase
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Authors
Kyle J. Gellatly, Kyong Sup Yoon, Jeffery J. Doherty, Weilin Sun, Barry R. Pittendrigh, J. Marshall Clark,