Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8349520 | Pharmacological Reports | 2018 | 30 Pages |
Abstract
Our data indicate that prolonged administration of antidepressants targets expression of KYNA biosynthetic enzymes. Furthermore, post-translational modulation of KATs seems to play an important role in tuning of KYNA synthesis within brain structures. We suggest that consistent increase of hippocampal KYNA levels may represent hallmark of antidepressant activity. Mechanisms governing region- and drug-selective action of antidepressants require further investigations.
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Authors
Tomasz Kocki, Ewa M. UrbaÅska, Janusz Kocki, Renata Kloc, Katarzyna Kocka, Marcin Olajossy, Björn Owe-Larsson,