| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8349542 | Pharmacological Reports | 2018 | 7 Pages |
Abstract
The differential sensitivity of basal synaptic transmission and LTP to MEK inhibition indicates that the effects of SYNGAP1 deficiency on these synaptic parameters are mediated by distinct pathways. Our findings also suggest that at least some physiological phenotypes of the germline Syngap1 mutation can be ameliorated by pharmacological treatment of adult animals.
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Authors
Maksym V. Kopanitsa, Gemma Gou, Nurudeen O. Afinowi, Ãlex Bayés, Seth G.N. Grant, Noboru H. Komiyama,