Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8349850 | Pharmacological Reports | 2017 | 24 Pages |
Abstract
This study showed that drug M2000 as a novel NSAID with immunosuppressive property is able strongly to inhibit the activity of COX-1/COX-2 enzymes, with suppressing the gene expression of COX-2 specifically. Therefore, based on gene expression findings this drug might be categorized and introduced as a novel NSAID with selective COX-2 inhibitory effect.
Keywords
β-d-mannuronic acidTxA2PLA2SOCS1TRAF6PGSIRAK1LTAPBMCsEAEm2000TXSSHIP1PGE2COX-1COX-2NSAIDSPGHSCOXLPSProstaglandin endoperoxide H synthaseTNFMMP3′-UTR3′-untranslated regioncyclooxygenasephospholipase A2experimental autoimmune encephalomyelitisArachidonic acidlipoteichoic acidstandard deviationanalysis of varianceANOVAThromboxane A2ThromboxanesBUNNon-steroidal anti-inflammatory drugssuppressor of cytokine signaling 1peripheral blood mononuclear cellsTNF receptor-associated factor 6tumor necrosis factorlipopolysaccharidematrix metalloproteinaseblood urea nitrogenProstaglandinsinterleukin-1 receptor-associated kinase 1
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Authors
Abbas Mirshafiey, Mahsa Taeb, Seyed Shahabeddin Mortazavi-Jahromi, Fahimeh Jafarnezhad-Ansariha, Bernd H.A. Rehm, Emanuela Esposito, Salvatore Cuzzocrea, Hidenori Matsuo,