Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8361940 | Seminars in Cancer Biology | 2017 | 21 Pages |
Abstract
While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we aimed at delineating details by which metabolic alterations in cancer cells, characterized by mitochondrial bioenergetics deregulations and the preference for aerobic glycolysis, are critical parameters controlling the aggressive progression of tumours. In particular, metabolic alteration in cancer cells are coupled to the modulation of intracellular and extracellular pH, epithelial-to-mesenchymal transition and associated increased invasiveness, autophagy, and the development of anticancer treatment resistance. Finally, based on mechanistic, pre-clinical and clinical studies, we proposed the adjuvant supplementation of dietary n-3 polyunsaturated fatty acids for a complementary holistic treatment of the cancer disease.
Keywords
Drp1TCA18-fluorodeoxyglucoseOXPHOSPPIMCTPPAR5-FluorouracileNMUbHLHECMIFPHIFUCP-2NHEP-gpPDH18FDGTMZN-Nitroso-N-methylureaMMP5-FUα-SMAmitochondrial uncoupling protein 2MDREPAAMPKmCATSodium-proton exchangerAMP-activated protein kinaseERK1/2MAPKn-3 PUFAn-3 Polyunsaturated fatty acidsP-glycoproteinROSbasic helix-loop-helixdocosahexaenoic acid (22:6n-3)n-3 polyunsaturated fatty acidα-smooth muscle actinTemozolomidePositron emission tomographyEMTDHACancer cell metabolismHypoxia-inducible factorOxidative phosphorylationInterstitial fluid pressurelactate dehydrogenaseLDHExtracellular matrixMatrix metalloproteinasesMultidrug resistanceProton pump inhibitorNavPETdynamin-related protein 1mitogen-activated protein kinasepyruvate dehydrogenasetricarboxylic acid cyclevoltage-gated sodium channelsextracellular signal-regulated kinaseepithelial-to-mesenchymal transitionReactive oxygen speciesPeroxisome proliferator activated receptor
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Authors
Jean-François Dumas, Lucie Brisson, Stéphan Chevalier, Karine Mahéo, Gaëlle Fromont, Driffa Moussata, Pierre Besson, Sébastien Roger,