Nitrogen signaling and use efficiency in plants: what's new?

Crop productivity is heavily dependent on the application of nitrogen (N) fertilizers. Increasing N fertilization levels, however, are subject to diminishing returns, quite apart from their deleterious impact on the environment. Improving N use efficiency (NUE) is therefore crucial for development of sustainable agriculture. Plant NUE is a complex trait determined by quantitative trait loci and influenced by environmental changes. The natural supply of soil N varies and is frequently limiting for plant growth and crop yield: unraveling the molecular basis of how plants sense and respond to changes in N availability should enable the development of new strategies to increase NUE. This review discusses the latest advances in our understanding of N signaling and crosstalk with other signaling pathways.