| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8384087 | FEBS Letters | 2008 | 8 Pages |
Abstract
Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.
Keywords
CNVFITCAMDCrryRPEChoroidal neovascularizationAlcoholretinal pigment epitheliumComplement systemMacular degenerationAge related macular degenerationVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fluorescein isothiocyanateMACNeovascularizationNicotinemembrane attack complexChoroid
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Authors
Sankaranarayanan Kaliappan, Purushottam Jha, Valeriy V. Lyzogubov, Ruslana G. Tytarenko, Nalini S. Bora, Puran S. Bora,