Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8384150 | FEBS Letters | 2006 | 5 Pages |
Abstract
Yeast cells lacking the metacaspase-encoding gene YCA1 (Îyca1) were compared with wild-type (WT) cells with respect to the occurrence, nature and time course of acetic-acid triggered death. We show that Îyca1 cells undergo programmed cell death (PCD) with a rate lower than that of the WT and that PCD in WT cells is caused at least in part by the caspase activity of Yca1p. Since in Îyca1 cells this effect is lost, but z-VAD-fmk does not prevent both WT and Îyca1 cell death, PCD in WT cells occurs via a Yca1p caspase and a non-caspase route with similar characteristics.
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Authors
Nicoletta Guaragnella, Clara Pereira, Maria João Sousa, Lucia Antonacci, Salvatore Passarella, Manuela Côrte-Real, Ersilia Marra, Sergio Giannattasio,