Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8384154 | FEBS Letters | 2008 | 5 Pages |
Abstract
By bioluminescence imaging and hydrodynamic gene transfer technology, the activities of hepatitis B virus (HBV) promoters and the effects of HBV enhancers on these promoters in mice under true physiological conditions have been assessed. Our studies reveal that either of the two HBV enhancers can stimulate HBV major promoter activity in hepa 1-6 cells (in vitro) and in mouse liver (in vivo), and the enhancer effects on the three promoters (S1, S2 and X promoter) are markedly greater in vivo than in vitro. The two HBV enhancers have no cooperative action on HBV promoters in vitro or in vivo.
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Authors
Juan Du, Yong Zhou, Qiu-Xia Fu, Wei-Li Gong, Fang Zhao, Jian-Chun Peng, Lin-Sheng Zhan,