Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8384167 | FEBS Letters | 2006 | 6 Pages |
Abstract
The majority of intrinsic rho-independent terminator signals, reported to consist of stable hairpin structures followed by T-rich regions, possess the potential to operate bi-directionally and to induce transcription terminations on both strands of the DNA duplex in Escherichia coli. By using RNAMotif software, we investigated the distributions of termination motifs around the 3â²-ends of overlapping and non-overlapping genes at the genomic level. We suggest that the positions of compactly encoded E. coli genes and rho-independent terminators are optimized to terminate the adjoining genes on their antisense strands efficiently, and not to mis-terminate overlapping transcripts, due to their bi-directional properties.
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Authors
Nozomu Yachie, Kazuharu Arakawa, Masaru Tomita,