Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8424965 | Stem Cell Research | 2018 | 4 Pages |
Abstract
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood characterized by expansion of clonal myelomonocytic cells and hyperactive Ras/MAPK signaling. The disorder is caused by somatic and/or germline mutations in genes involved in the Ras/MAPK and JAK/STAT signaling pathways, including CBL. Here we describe the generation of an iPSC line with a homozygous CBL c.1111T->C (Y371H) mutation, designated CHOPJMML1854.
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Authors
Alyssa L. Gagne, Jean Ann Maguire, Shilpa Gandre-Babbe, Stella T. Chou, Sarah K. Tasian, Mignon L. Loh, Mitchell J. Weiss, Paul Gadue, Deborah L. French,