Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8425314 | Stem Cell Research | 2018 | 5 Pages |
Abstract
Best disease (BD), also termed Best vitelliform macular dystrophy (BVMD), is a juvenile-onset form of macular degeneration and central visual loss. In this report, we generated an induced pluripotent stem cell (iPSC) line, TVGH-iPSC-012-04, from the peripheral blood mononuclear cells of a female patient with BD by using the Sendai virus delivery system. The resulting iPSCs retained the disease-causing DNA mutation, expressed pluripotent markers and could differentiate into three germ layers. We believe that BD patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease.
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Authors
Chih-Chien Hsu, Huai-En Lu, Jen-Hua Chuang, Yu-Ling Ko, Yi-Ching Tsai, Hsiao-Yun Tai, Aliaksandr A. Yarmishyn, De-Kuang Hwang, Mong-Lien Wang, Yi-Ping Yang, Shih-Jen Chen, Chi-Hsien Peng, Shih-Hwa Chiou, Tai-Chi Lin,