Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8425403 | Stem Cell Research | 2018 | 5 Pages |
Abstract
Human iPSCs generated from CADASIL patients will A) facilitate studies of developmental biology of endothelial cells and vascular smooth muscular cells pathologically disrupted in CADASIL; B) yield endothelial and vascular smooth muscular cells for in vitro CADASIL model for drug screening and C) help to establish the therapeutic utility of iPSCs corrected by CRISPR-Cas9 in animal models of CADASIL (e.g., in Notch3â/â mice).167
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Héctor Fernández-Susavila, Cristina Mora, Marta Aramburu-Núñez, Rita Quintas-Rey, Susana Arias, Manuel Collado, Esteban López-Arias, Tomás Sobrino, José Castillo, Patrizia Dell'Era, Francisco Campos,