| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8425539 | Stem Cell Research | 2018 | 4 Pages |
Abstract
Cytochrome P450 (CYP) comprises a superfamily of monooxygenase responsible for the metabolism of xenobiotics and approximately 75% of drugs in use today. Thus, genetic polymorphisms in CYP genes contribute to interindividual differences in hepatic metabolism of drugs, affecting on individual drug efficacy and may cause adverse effects. Here, we generated a human induced pluripotent stem cell (hiPSC) line with pharmacologically important traits (CYP2C19*2/CYP3A5*3C), which are highly polymorphic in Asian from lymphoblastoid cells. This hiPSC line could be a valuable source for predicting individual drug responses in the drug screening process that uses hiPSC-derived somatic cells, including hepatocytes.
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Authors
Jaehun Lee, Dong-Hun Woo, Han-Jin Park, Kijung Park, Duck Sung Ko, Jong-Hoon Kim,