| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8425748 | Stem Cell Research | 2017 | 38 Pages |
Abstract
hiPSC-NPCs-derived neurospheres seem to be useful for DNT evaluation representing early neural development in vitro. More system characterization by compound testing is needed to gain higher confidence in this method.
Keywords
MEALOAECNPMNDMDNThESCsTGF-β3hiPSCsEBsGDNFTTXBDNFBMPsNPCsMicroelectrode arraysTestingnimtetrodotoxinembryoid bodiesIn vitroBrain developmentStem cellHuman induced pluripotent stem cellshuman embryonic stem cellsNeural progenitor cellsDevelopmental neurotoxicityGlial cell line-derived neurotrophic factorBrain-derived neurotrophic factornot detectablegestational weekbone morphogenic proteinsMethylmercury chloride
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Authors
Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche,