Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8425765 | Stem Cell Research | 2017 | 12 Pages |
Abstract
We conclude that ajmaline can block both depolarisation and repolarisation of hiPSC-CMs at the cellular level, but that a more refined integrated tissue model may be necessary to elicit differences in its effect between BrS patients and controls.
Keywords
MEAhiPSCIKrNGSAjmalineBR1HDFsBRSHpSCFPDAPDRMPINamulti electrode arrayECGelectrocardiogramNext generation sequencingHuman pluripotent stem cellHuman induced pluripotent stem cellBrugada syndromeActivation-recovery intervalHuman dermal fibroblastsVentricular fibrillationCardiomyocyteAction potential durationfield potential durationaction potentialresting membrane potentialField potential
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Authors
Duncan C. Miller, Stephen C. Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C. Edwards, James S. Ware, Tyson V. Sharp, Tristan R. McKay, Leo Dunkel, Pier D. Lambiase, Andrew Tinker,