Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8425773 | Stem Cell Research | 2017 | 4 Pages |
Abstract
Ras-related protein 39B (RAB39B) mutation has been reported as a potential cause of X-linked Parkinson's disease (PD), a rare form of familial PD. Recently, a novel RAB39B mutation was identified in an X-linked juvenile parkinsonism family and the dermal fibroblasts of the patient were obtained and successfully induced to induced pluripotent stem cells (iPSCs) by the human OSKM transcription factors using the Sendai-virus delivery system. Our model may offer a good platform for further research of the pathomechanism, drug testing, and gene therapy of this disease.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biotechnology
Authors
Yanlin Wang, Huifang Sun, Zhilei Wang, Zhihua Yang, Mengmeng Shi, Jing Yang, Yutao Liu, Han Liu, Shuo Zhang, Changhe Shi, Yuming Xu,