Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8469581 | European Journal of Cell Biology | 2018 | 58 Pages |
Abstract
Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs have been of special interest in several scientific and industrial fields, including recombinant protein production, disease diagnosis, immunization, and laboratory techniques. Recently, the role of SPs in recombinant protein production has gained too much attention. Herein, several studies have been reviewed to elucidate the precise structure and function of SPs, particularly the optimized ones for recombinant protein production. However, some features of SPs still have remained obscure. In this review, some approaches concerning elucidation and optimization of SPs are discussed, and pragmatic conclusions and suggestions for future studies are also proposed. Moreover, a summary of secretory pathways, evolutionary changes, functions, applications, and different types of SPs is mentioned. At last, current limitations and prospects are discussed.
Keywords
OPHPhenol soluble modulinVSV-GLCMVLHCGRPGHECPPSMHASToMRBPGM-CSFDNPTgf-αSPPTIMSPaseBEVSMPPTPPMIPSPCMBPCSNPTHrPPMFnuclear magnetic resonancehuman serum albuminALPAlkaline phosphataseamino acidtranslocase of outer membraneMAStransforming growth factor-αNMRFunctionsTorATIRmagic angle spinningCAMStructureNatural killer cellbaculovirus expression vector systemsignal peptidase complexendoplasmic reticulumDynamic nuclear polarizationTranslation initiation regionproton motive forcePorcine growth hormoneOrganophosphorus hydrolaseLymphocytic choriomeningitis virusmitochondrial processing peptidasemaltose-binding proteinParathyroid hormone related proteinEosinophil cationic proteinSignal peptideSignal peptidaseMitochondrial intermediate peptidaseCadACalmodulinChitosanase
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Authors
Hajar Owji, Navid Nezafat, Manica Negahdaripour, Ali Hajiebrahimi, Younes Ghasemi,