Diet-delivery of therapeutic RNA interference in live Escherichia coli against pre-existing Penaeus merguiensis hepandensovirus in Penaeus merguiensis

Overall, this study showed that RNAi microencapsulated in live E. coli and fed via pelleted feed could increase survival of P. merguiensis and lower viral copies in pre-existing infections of PmeDV. This methodology herein should be the simplest for farmers to apply and when utilized, these results should allow farmers to increase yields, profitability and therefore, sustainability.