Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8496481 | Aquaculture | 2007 | 7 Pages |
Abstract
Maximum TRR of 71Â ng/g and 3857Â ng/mL (ivermectin equivalent concentration) were detected in muscle and bile, respectively, by sample oxidation on post-dose day 3. LC analysis of the muscle extract revealed that the maximum TRR of 55Â ng/g (representing ivermectin and metabolites) was also detected on post-dose day 3. By post-dose day 35, about 65% of the TRR in the muscle tissue was an unknown metabolite. Preliminary mass spectrometry results indicated that the unknown metabolite may be 3â³-O-demethyl-ivermectin B1a. This metabolite could serve as a potential marker residue for ivermectin in rainbow trout, in contrast to cattle, swine and sheep where the parent ivermectin is known to be the marker residue.
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Authors
Badar Shaikh, Nathan Rummel, Charles Gieseker, Pak-Sin Chu, Renate Reimschuessel,