Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8500382 | Journal of Comparative Pathology | 2018 | 4 Pages |
Abstract
Stem cell factor (SCF) is a ligand of the molecule Kit, which is expressed in mast cells and is important for mast cell proliferation, migration and survival. Mast cell tumours (MCTs) are associated with mutations of c-kit, a proto-oncogene encoding the Kit protein. In this study, we examined SCF expression in 23 samples of feline MCTs. SCF expression was detected in 10 cutaneous MCTs and a case of splenic mastocytosis. In the cutaneous MCTs, SCF-positive tumour cells were located at the margins. Kit was expressed in eight of the 10 cutaneous cases of SCF-expressing MCTs. In these cases, Kit-positive cells were located near to SCF-positive cells, and SCF/Kit double-positive tumour cells were found. Ki67-positive tumour cells were not found near to SCF-positive cells. These results suggest that SCF autocrine/paracrine mechanisms are involved in the expansion of cutaneous MCTs, but not in tumour proliferation.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Animal Science and Zoology
Authors
M. Sakurai, R. Iwasa, Y. Sakai, J.K. Chambers, K. Uchida, M. Morimoto,