| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8500458 | Journal of Comparative Pathology | 2018 | 5 Pages |
Abstract
The aim of this study was to document the molecular clonality of lymphoid cells in canine thymoma using polymerase chain reaction for antigen receptor rearrangement (PARR). Fifteen formalin-fixed and paraffin wax-embedded samples of canine thymoma were analyzed for T- and B-cell receptor clonality. Two of these 15 cases were excluded from the study due to insufficient DNA concentration. Twelve of the 13 remaining samples (92.3%) showed a polyclonal lymphoid component and in one case the lymphoid component was monoclonal (T-cell clonality). PARR could therefore be a useful tool for differentiating canine thymoma from canine mediastinal lymphoma.
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Authors
F. Vessieres, R. Rasotto, I. Peters, E. Villiers, D. Berlato, F. Cian,