Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8503884 | Research in Veterinary Science | 2018 | 5 Pages |
Abstract
This study examined the predictive value of serum cystatin C (Cys-C) concentration, measured during routine periodic health examinations, in the renal prognosis of dogs. A cohort of 140 dogs weighing <15â¯kg whose serum Cys-C concentrations were measured during periodic health examinations from December 2013 to March 2016 were prospectively studied, with renal disease-related death the predicted end point. Of the 140 dogs, nine died from renal diseases during the follow-up period (539â¯Â±â¯249â¯days). Serum Cys-C concentrations were higher in the dogs that subsequently died of renal disease than in the censored group (0.8â¯Â±â¯0.25 vs. 0.3â¯Â±â¯0.1â¯mg/dl, respectively; Pâ¯<â¯.01). Dogs with high serum Cys-C concentrations (>0.55â¯mg/dl) had a shorter (Pâ¯<â¯.01) renal disease-specific survival period than those with low serum Cys-C concentrations (â¤0.55â¯mg/dl). In conclusion, high serum Cys-C concentrations in periodic health examinations in dogs <15â¯kg predicted poorer prognosis for renal function.
Keywords
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Authors
Naoki Iwasa, Satoshi Takashima, Tatsuo Iwasa, Kazuko Iwasa, Tomomi Suzuki, Yui Kobatake, Hitoshi Kitagawa, Naohito Nishii,