Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8503938 | Research in Veterinary Science | 2018 | 11 Pages |
Abstract
Horses metabolic disorders have become an important problem of modern veterinary medicine. Pathological obesity, insulin resistance and predisposition toward laminitis are associated with Equine Metabolic Syndrome (EMS). Based on pathogenesis of EMS, dietary and cell therapy management may significantly reduce development of this disorder. Special attention has been paid to the diet supplementation with highly bioavailable minerals and mesenchymal stem cells (MSC) which increase insulin sensitivity. In nutrition, there is a great interests in natural algae enriched via biosorption process with micro- and macroelements. In the case of cellular therapy, metabolic condition of engrafted cells may be crucial for the effectiveness of the therapy. Although, recent studies indicated on MSC deterioration in EMS individuals. Here, we described the combined nutritional and stem cells therapy for the EMS treatment. Moreover, we specified in details how EMS affects the adipose-derived stem cells (ASC) population. Presented here, combined kind of therapy- an innovative and cutting edge approach of metabolic disorders treatment may become a new gold standard in personalized veterinary medicine.
Keywords
ALADJDEPAPGCAGEsDPAMSCEMSMVSPARLKERNSCIPCROSalpha-linolenic acidEicosapentaenoic aciddocosapentaenoic aciddocosahexaenoic acidDiabetesDegenerative joint diseaseEnzyme-linked immunosorbent assayELISANutritionAlgaeDHASODMesenchymal stem cellsInsulin producing cellsMetabolic syndromeEquine metabolic syndromeSuperoxide dismutaseAdvanced glycosylation end productsObesityInsulin resistanceNitric oxideNon-structural carbohydratesIECsReactive oxygen species
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Authors
Krzysztof Marycz, Izabela Michalak, Katarzyna Kornicka,