Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8504651 | Veterinary Immunology and Immunopathology | 2018 | 5 Pages |
Abstract
In this work, we used immunohistochemistry and digital image analysis to evaluate the presence of IDO in granulomas at different stages of development in cattle that had been BCG-vaccinated or not and then challenged with M. bovis. Our results show that the expression of IDO in granulomas from non-vaccinated M. bovis challenged animals is higher than in granulomas from BCG-vaccinated M. bovis challenged animals. Thus, it is possible that vaccination with BCG prevents the induction of what are thought to be host immunosuppressive pathways by M. bovis, which contribute to pathology during the disease.
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Authors
Waldo L. Garcia-Jimenez, Bernardo Villarreal-Ramos, Duncan Grainger, R. Glyn Hewisnon, Hans M. Vordermeier, Francisco J. Salguero,