Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8504870 | The Veterinary Journal | 2018 | 4 Pages |
Abstract
Serum canine α1-proteinase inhibitor (cα1-PI) concentrations were evaluated in dogs with pancreatitis (n = 24), exocrine pancreatic insufficiency (EPI; n = 29), chronic hepatitis (CH; n = 11) or proteinuric chronic kidney disease (CKD-P; n = 61) to determine whether systemic proteinase/proteinase-inhibitor balance is altered in these conditions. Dogs with CKD-P had significantly lower cα1-PI concentrations than dogs with pancreatitis, EPI or CH; 16% of dogs with CKD-P had serum cα1-PI concentrations below the reference interval. Serum and urine cα1-PI concentrations were inversely correlated in dogs with CKD-P, but not in dogs with CH. This suggests that renal loss of cα1-PI contributes to decreased serum concentrations in dogs with CKD-P, while hepatic cα1-PI synthesis with CH either is not compromised or is counterbalanced by extrahepatic production.
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Authors
R.M. Heilmann, N. Grützner, J.A. Hokamp, J.A. Lidbury, P.G. Xenoulis, J.S. Suchodolski, M.B. Nabity, R. Cianciolo, J.M. Steiner,