Streptoxamine, an unprecedented benzoisoindole-deferoxamine hybrid from the locust-derived Streptomyces sp. HKHCa2

An unusual benzoisoindole-deferoxamine hybrid, streptoxamine (1), was isolated from the fermentation broth of an locust-associated Streptomyces sp. HKHCa2. This natural product features a hybrid pattern of a benzoisoindole with an “iron carrier” deferoxamine B through C-N linkage, and showed weak antibacterial activity against the gram-positive bacteria, Staphylococcus aureus and Mycobacterium smegmatis.119