Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8532691 | Journal of Ethnopharmacology | 2016 | 71 Pages |
Abstract
Based on our review, Cornus mas L. (cornelian cherry) fruits and leaves can be used mainly in the treatment of diabetes, obesity, atherosclerosis, skin diseases, gastrointestinal and rheumatic problems. Some indications from ethnomedicines have been validated by pharmacological activities of the fruits and its extracts/pure isolates. The reported data reveal that the fruits are a potential source for treatment of diabetes, obesity, hyperlipidemia and gastrointestinal disorders. Unfortunately, the pharmacological studies in these areas are still insufficient to substantiate these preventive effects in confirmatory trials on the mass-scale clinical settings. Future studies on mechanisms of action, bioavailability, pharmacokinetics and adverse effects of the extracts and their bioactive constituents as well as their effective doses and long term toxic effects in humans are needed for commercial applications of these extracts/isolates in modern medicines. The available literature showed that most of the activities of the extracts are due to their constituents, anthocyanins, flavonoids and other phenolics, iridoids and vitamins for their antioxidant and other properties.
Keywords
AIPPBSTNFαIL-6COXLD50DPPHBHTORACABTSCATCGECCFBHAIC50AAPHGSHGPXFRAPICAM-1NF-kBGITISSRRAPDAFLPIBDCUPRACcupric ion reducing antioxidant capacityTEACEC50GAEALTAAELDL-CFCRRFLPPONPPARαGIDSTZHDL-CiOpPcGIL-8PDWApo A1MTXIFNγVCAM-1VLDLIKKβCornus mas L.ALR2Cornelian cherryMDAFolin-Ciocalteu reagent2,2′-azobis(2-amidinopropane) dihydrochloride2,2-diphenyl-1-picrylhydrazylapo BRandomly amplified polymorphic DNAMTTAqueousASTAspartate aminotransferaseAlanine aminotransferaseAldose reductaseperoxisome proliferator-activated receptor alphaALPAlkaline phosphatasecyclooxygenaseApolipoprotein A1Apolipoprotein BEthnomedicineGastrointestinal disorderstreptozotocinHydrogen atom transferelectron transferinterferon γInterleukin-8interleukin-6Alzheimer's diseaseInflammatory bowel diseasetriglyceridetumor necrosis factor alphaaq.Gastrointestinal tractInter simple sequence repeatSODSuperoxide dismutaseTrolox equivalent antioxidant capacityoxygen radical absorbance capacityPlatelet distribution widthExtractsconcentrationPharmacologynuclear factor kappaBIntraocular pressurePhytochemistrylactate dehydrogenaseLDHvery low density lipoproteinmalondialdehydeMethotrexatephosphate buffer solutionascorbic acid equivalentGallic acid equivalenttrolox equivalentintracellular adhesion molecule-1vascular cell adhesion molecule-1glycated haemoglobinbody weightfresh weightdry weightAmplified fragment length polymorphismrestriction fragment length polymorphismCatalaseferric reducing antioxidant powerCreatine kinaseHATtotal cholesterolhigh density lipoprotein cholesterollow density lipoprotein cholesterolPositive controlCornus masThiol groupsProtein carbonyl groupsGlutathioneglutathione peroxidase
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Biswanath Dinda, Anthony M. Kyriakopoulos, Subhajit Dinda, Vassilis Zoumpourlis, Nikolaos S. Thomaidis, Aristea Velegraki, Charlambos Markopoulos, Manikarna Dinda,