Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry

Article ID	Journal	Published Year	Pages	File Type
8532691	Journal of Ethnopharmacology	2016	71 Pages	PDF

Abstract

Based on our review, Cornus mas L. (cornelian cherry) fruits and leaves can be used mainly in the treatment of diabetes, obesity, atherosclerosis, skin diseases, gastrointestinal and rheumatic problems. Some indications from ethnomedicines have been validated by pharmacological activities of the fruits and its extracts/pure isolates. The reported data reveal that the fruits are a potential source for treatment of diabetes, obesity, hyperlipidemia and gastrointestinal disorders. Unfortunately, the pharmacological studies in these areas are still insufficient to substantiate these preventive effects in confirmatory trials on the mass-scale clinical settings. Future studies on mechanisms of action, bioavailability, pharmacokinetics and adverse effects of the extracts and their bioactive constituents as well as their effective doses and long term toxic effects in humans are needed for commercial applications of these extracts/isolates in modern medicines. The available literature showed that most of the activities of the extracts are due to their constituents, anthocyanins, flavonoids and other phenolics, iridoids and vitamins for their antioxidant and other properties.

Keywords

AIP PBS TNFα IL-6 COX LD50 DPPH BHT ORAC ABTS CAT CGE CCF BHA IC50 AAPH GSH GPX FRAP ICAM-1 NF-kB GIT ISSR RAPD AFLP IBD CUPRAC cupric ion reducing antioxidant capacity TEAC EC50 GAE ALT AAE LDL-C FCR RFLP PON PPARα GID STZ HDL-C iOp PcG IL-8 PDW Apo A1 MTX IFNγ VCAM-1 VLDL IKKβ Cornus mas L.ALR2 Cornelian cherry MDA Folin-Ciocalteu reagent 2,2′-azobis(2-amidinopropane) dihydrochloride 2,2-diphenyl-1-picrylhydrazyl apo B Randomly amplified polymorphic DNA MTT Aqueous AST Aspartate aminotransferase Alanine aminotransferase Aldose reductase peroxisome proliferator-activated receptor alpha ALP Alkaline phosphatase cyclooxygenase Apolipoprotein A1 Apolipoprotein B Ethnomedicine Gastrointestinal disorder streptozotocin Hydrogen atom transfer electron transfer interferon γ Interleukin-8 interleukin-6 Alzheimer's disease Inflammatory bowel disease triglyceride tumor necrosis factor alpha aq.Gastrointestinal tract Inter simple sequence repeat SOD Superoxide dismutase Trolox equivalent antioxidant capacity oxygen radical absorbance capacity Platelet distribution width Extracts concentration Pharmacology nuclear factor kappaB Intraocular pressure Phytochemistry lactate dehydrogenase LDH very low density lipoprotein malondialdehyde Methotrexate phosphate buffer solution ascorbic acid equivalent Gallic acid equivalent trolox equivalent intracellular adhesion molecule-1 vascular cell adhesion molecule-1 glycated haemoglobin body weight fresh weight dry weight Amplified fragment length polymorphism restriction fragment length polymorphism Catalase ferric reducing antioxidant power Creatine kinase HAT total cholesterol high density lipoprotein cholesterol low density lipoprotein cholesterol Positive control Cornus mas Thiol groups Protein carbonyl groups Glutathione glutathione peroxidase