Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8533485 | Journal of Pharmacological Sciences | 2017 | 4 Pages |
Abstract
Given that Cav3.2 T-type Ca2+ channels were functionally regulated by asparagine (N)-linked glycosylation, we examined effects of high glucose on the function of Cav3.2, known to regulate secretory function, in neuroendocrine-like differentiated prostate cancer LNCaP cells. High glucose accelerated the increased channel function and overexpression of Cav3.2 during neuroendocrine differentiation, the former prevented by enzymatic inhibition of N-glycosylation and cleavage of N-glycans. Hyperglycemia thus appears to induce N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 in neuroendocrine-like differentiated prostate cancer cells.
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Authors
Kazuki Fukami, Erina Asano, Mai Ueda, Fumiko Sekiguchi, Shigeru Yoshida, Atsufumi Kawabata,