A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

Article ID	Journal	Published Year	Pages	File Type
8536597	Pharmacological Research	2018	31 Pages	PDF

Keywords

ABC PI3K TNBC MMP DAB PBS ATD Jnk SPF PDA EtOH GAPDH CSCs TLC mTOR HRP Bcl-2 SFA RIPA UPR LC3 p62 GSK3β PARP JC-1 MTD TdT AEC ATG5 EtOAc 7-AAD RTCA SAPKs 7-amino-actinomycin D tetramethylsilane TMS terminal deoxynucleotidyl transferase dUTP nick end labelling autophagy protein 5 WFI low-density lipoprotein receptor-related protein 6 3-amino-9-ethyl carbazole 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide BiP/Grp78 C/EBP homologous protein c-Jun N-terminal kinase DMSO ESI–MS IRE1α MTT NOD/SCID water for injection adenosine-5′-triphosphate ATP photodiode array Radio immunoprecipitation assay Ethanol Ethyl acetate Endoplasmic reticulum stress SDS-PAGE Sodium dodecyl sulfate polyacrylamide gel electrophoresis Tem dishevelled terminal deoxynucleotidyl transferase Triterpenoid NMR TUNEL CHOP Maximum tolerated dose diaminobenzidine Dimethyl sulfoxide Triple negative breast cancer Cancer stem cells Ubiquitin proteasome system cell index endoplasmic reticulum Ultraviolet spectroscopy electrospray ionisation mass spectrometry Infrared spectroscopy inhibitory concentration Phosphate buffered saline phosphatase and tensin homolog phosphoinositide 3-kinase B-cell lymphoma 2 Mammosphere Methanol MeOH Transmission electron microscopy mammalian target of rapamycin specific pathogen free Unfolded protein response Mitochondrial membrane potential Horseradish peroxidase protein kinase B Propidium iodide poly (ADP-ribose) polymerase Pten HPLC high-performance liquid chromatography thin-layer chromatography Chloroquine negative control ATP-binding cassette stress-activated protein kinases glyceraldehyde 3-phosphate dehydrogenase glycogen synthase kinase 3 beta UPS

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A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

Authors

Buse Cevatemre, Merve ErkÄ±sa, Nazlihan Aztopal, Didem Karakas, PÄ±nar Alper, Chrisiida Tsimplouli, Evangelia Sereti, Konstantinos Dimas, Elif I. Ikitimur Armutak, Ebru Gurel Gurevin, Ayca Uvez, Mattia Mori, Simone Berardozzi, Cinzia Ingallina,