Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8646469 | Infection, Genetics and Evolution | 2018 | 19 Pages |
Abstract
Deep Sea sediment cores were collected from the surrounding of active volcanic Barren Island, Andaman & Nicobar Islands. A total of 24â¯halophilic eubacteria were isolated and identified based on their biochemical and 16S rDNA sequences. Three major classes (Gamma-Proteobacteria, Alpha-Proteobacteria and Bacilli) of bacteria were detected in the deep sea sediments of active volcanic Barren Island. Among those, 37% of isolates exhibited antimicrobial activity against all tested Gram positive and Gram negative clinical pathogens. 60% of isolates revealed the presence of either PKS or NRPS genes and 65% isolates disclosed medium to higher level of cytotoxicity in MB-231 breast cancer cell line. Majority of the isolates revealed excellent potential for bioprospecting of novel byproducts with industrial and pharmaceutical importance.
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Authors
Anburajan Lawrance, Meena Balakrishnan, Rajaprabhu Gunasekaran, Rajaguru Srinivasan, Vinithkumar Nambali Valsalan, Dharani Gopal, Kirubagaran Ramalingam,