Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8646606 | Infection, Genetics and Evolution | 2018 | 30 Pages |
Abstract
The phylogenetic analysis of the HCV-1a sequences from the studied patient showed that he was co-infected with three different viral lineages. These lineages were not evenly detected throughout time. The sequence diversity and coalescence analyses of these lineages suggested the action of different evolutionary patterns in different immune conditions: a slow rate, drift-like process in an immunocompromised condition (low levels of CD4+ T lymphocytes); and a fast rate, variant-switch process in an immunocompetent condition (high levels of CD4+ T lymphocytes).
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Authors
Culasso Andrés Carlos Alberto, Monzani MarÃa Cecilia, Baré Patricia, Campos Rodolfo Hector,