Analysis of CTLA-4Â +Â 49A/G gene polymorphism in cases with leprosy of Azerbaijan, Northwest Iran

The allelic and genotypic frequencies of + 49A/G gene polymorphism were similar in controls and patients. However, older ages, older age of onset and over-representation in male were observed in lepromatous leprosy patient carriers of GG genotype. The current study demonstrates that although CTLA-4 + 49A/G polymorphism was not correlated with a higher genetic risk for leprosy, the presence of a GG genotype was associated with older ages, older age of onset and over-representation in male in Iranian Azeri population.