Effect of combined exercise training on serum brain-derived neurotrophic factor, suppressors of cytokine signaling 1 and 3 in patients with multiple sclerosis

The concentration of serum SOCS1, SOCS3, and BDNF in the groups. Data are presented as median (IQR). *p < 0.05 (Wilcoxon test). MS-C: Control group with multiple sclerosis, MS-EX: Combined exercise group with multiple sclerosis. After 8 weeks, serum BDNF levels increased statistically in MS-EX (*p < 0.05) and SOCS1 increased significantly in MS-C (*p < 0.05).101