Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8876244 | Journal of Northeast Agricultural University (English Edition) | 2016 | 6 Pages |
Abstract
The aim of the study was to assess effect of the atipamezole on talezol/xylazine induced expression of c-fos in rat brain. Rats were injected with the mixture of 13.81 mg · kgâ1 telazol and 5.21 mg · kgâ1 xylazine, following 10 min later 0.522 mg · kgâ1 atipamezole injected, and then the cerebral cortex and thalamencephal were removed at 1 h after injected. Level of Fos protein was measured in the brain tissue by western-blot. The results revealed that telazol/xylazine induction Fos protein expression in the thalamencephal and cerebral cortex during the period of anesthesia, atipamezole attenuated telazol/xylazine induction Fos protein expression in the thalamencephal and cerebral cortex. The results indicated that atipamezole could inhibite telazol/xylazine-induced c-fos expression in the rat brain, and played a protective role of neuronal injury.
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Authors
Yin Bai-shuang, Gao Li, Fu Lian-jun, Hong-jin LI, Wang Hong-bin,